A TecExec-led project to investigate the milling of small crystalline active pharmaceutical ingredients (APIs) completed its formal completion assessment in April this year. However, work is continuing on the project which uses the Maelstrom ConCor mill to grind and then disperse API ingredients into common solvents to increase their surface area and therefore their reactivity and speed of absorption. Initial work on aspirin and ibuprofen crystals have shown promising results, with much higher throughputs than competitive milling methods.
Commenting on the results so far, David Brown of TecExec said, "This project is enabling us to demonstrate a practical application of Maelstrom's ConCor technology in solving a real problem for the pharmaceutical industry. We have suspected for some time that the ConCor could achieve this result, but with the support of Innovate UK, we have now been able to prove it."
